In vitro activity of cefazoline and cefuroxime in presence of essential and trace elements

Present research focuses to evaluate changes in antimicrobial activity of cefazolin sodium and cefuroxime after interactions with essential and trace elements. The minimum inhibitory concentration (MIC) was observed and subsequently compared with the standard MIC's of the respective drug by agar dilution method against a variety of Gram positive and Gram negative organisms. It was observed that these metal elements are essential for our body, either present within the body or co-administered with vitamins or otherwise, markedly influence the MIC's of antibiotics by producing synergism or antagonism.