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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

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Related Experiment Video

Updated: Jul 15, 2026

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

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Impact of cinematic viewing on endothelial function

M Miller, C Mangano, Y Park

Heart (British Cardiac Society)

|January 18, 2006

Summary

No abstract available in PubMed .

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Last Updated: Jul 15, 2026

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