Related Experiment Videos
Inhaled corticosteroid rapidly improved pulmonary sarcoidosis
Shoji Ohno1, Shoko Nakazawa, Akira Kobayashi
1Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, Tochigi, Japan.
Internal Medicine (Tokyo, Japan)
|January 18, 2006
Summary
Inhaled corticosteroids like budesonide show promise for treating pulmonary sarcoidosis. These treatments rapidly improved symptoms and imaging in two patients, offering a potential new option.
Area of Science:
- Pulmonary Medicine
- Rheumatology
Background:
- Pulmonary sarcoidosis is a multisystem inflammatory disease.
- Treatment options for pulmonary sarcoidosis can be limited.
Observation:
- Two patients with persistent pulmonary sarcoidosis symptoms and imaging findings were treated.
- One patient initially received fluticasone, then switched to budesonide.
- The second patient received budesonide in combination with oral steroids.
Findings:
- Budesonide therapy led to symptom resolution and improved chest X-ray findings in both patients.
- Serum angiotensin-converting enzyme (ACE) levels and pulmonary function improved.
- Treatment was generally well-tolerated over two to three months.
Implications:
- Inhaled corticosteroids may be a viable and tolerable treatment for select pulmonary sarcoidosis cases.
- Further research into inhaled corticosteroid efficacy in sarcoidosis is warranted.
- This approach could offer an alternative or adjunctive therapy for managing pulmonary sarcoidosis.
Related Concept Videos
01:26COPD: Management Using Bronchodilators and Corticosteroids
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
01:23Inhaled Medications
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
01:25Antiasthma Drugs: β2-Adrenoceptor Agonists
Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
01:19Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms: