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Encephalopathy with isolated reversible splenial lesion of the corpus callosum

Masamitsu Yaguchi1, Hisa Yaguchi, Tetsuro Itoh

  • 1Department of Neurology, Shinoda General Hospital, Yamagata, and the Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Japan.

Internal Medicine (Tokyo, Japan)
|January 18, 2006
PubMed

Insights

A man with alcoholism experienced confusion after infections. Brain MRI revealed a temporary lesion in the corpus callosum splenium, which resolved with full neurological recovery.

Area of Science:

  • Neurology
  • Radiology
  • Infectious Diseases

Background:

  • Chronic alcoholism is associated with various neurological complications.
  • Infections can trigger or exacerbate neurological symptoms in vulnerable individuals.

Observation:

  • A 51-year-old Japanese man with chronic alcoholism presented with mental confusion after respiratory and intestinal infections.
  • Magnetic Resonance Imaging (MRI) revealed characteristic changes in the splenium of the corpus callosum.

Findings:

  • The splenium of the corpus callosum demonstrated hyperintensity on diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery (FLAIR) sequences.
  • T1-weighted images showed hypointensity in the same region.
  • These splenial lesions resolved completely on follow-up MRI within 3 days.

Implications:

  • The findings suggest a case of mild encephalopathy with a reversible splenial lesion (MERS).
  • This condition can occur following systemic viral or bacterial infections in individuals with underlying risk factors like alcoholism.
  • Complete neurological recovery is possible with resolution of the splenial lesion.

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