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The effect of multipurpose solutions on the ocular surface.
Christopher W Lievens1, Natasha Hakim, Andrea Chinn
1Southern College of Optometry, Memphis, TN 38104, USA. clievens@sco.edu
Eye & Contact Lens
|January 18, 2006
Summary
Multipurpose contact lens solutions can cause adverse ocular surface effects. High-frequency use of ReNu solution, specifically its preservatives and additives, was linked to reduced tear breakup time and potential clinical signs.
Area of Science:
- Ophthalmology
- Optometry
- Corneal Science
Background:
- Multipurpose contact lens solutions (MPCS) are widely used for contact lens care.
- Previous studies have investigated the effects of MPCS on ocular surfaces, often considering the contact lens as a delivery vehicle.
- The independent contribution of MPCS to adverse ocular effects requires further investigation.
Purpose of the Study:
- To evaluate the potential of three specific MPCS—Bausch & Lomb ReNu MultiPlus, Alcon No Rub Opti-Free Express, and Advanced Medical Optics Complete Moisture Plus—to cause adverse ocular surface effects.
- To determine if MPCS preservatives and additives contribute to ocular surface issues when used frequently.
- To assess the relationship between MPCS use and contact lens-related complications.
Main Methods:
- A randomized study involving 21 subjects, with each subject using one of the three MPCS in their treatment eye four times daily, while the fellow eye served as a control.
- Ocular surface testing was performed at baseline and weekly intervals by a masked examiner.
- Statistical analysis included Friedman 1-way ANOVA for non-parametric data and 1-way repeated measures ANOVA for parametric data.
Main Results:
- A statistically significant reduction in tear breakup time (P < 0.05) was observed in the group using the ReNu solution.
- No specific mention of results for Opti-Free Express or Complete Moisture Plus in the provided abstract.
- The study focused on identifying significant changes in ocular surface parameters related to MPCS use.
Conclusions:
- The ReNu multipurpose contact lens solution, particularly its preservatives and additives, may be cytotoxic and contribute to adverse ocular surface effects when used frequently.
- Frequent use of ReNu may be linked to contact lens dropout and observable clinical signs in patients.
- Further research is warranted to fully elucidate the role of MPCS in ocular surface health and patient compliance.