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A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
[Study on treatment effectiveness and safety in children with chronic hepatitis B or C using bicyclo tablets]
Hong-fei Zhang1, Xiao-jin Yang, Shi-shu Zhu
1Department of Pediatric Liver Disease, The No. 302 Hospital of The People's Liberation Army, Beijing 100039, China.
Background:
To evaluate treatment effectiveness and safety of bicyclo tablets in children with chronic hepatitis B or C.
Methods:
A randomized controlled trial was conducted in 148 children with chronic hepatitis B or C for evaluating safety, tolerability, and efficacy of treatment with bicyclo tablets or Hugan tablets. Children in therapy group were treated with bicyclo tablets and control group treated with Hugan tablets.
Results:
(1) ALT and AST level decreased more prominently in therapy group than in control group (P<0.01). (2) Bicyclo was more effective than Hugan tablets (P<0.01). (3) Symptoms were ameliorated more prominently in bicyclo group than in control group (P<0.01). (4) Both groups had no significant adverse events.
Conclusion:
Satisfactory therapeutic effect and safety were obtained with bicyclo tablets in children with chronic hepatitis B or C.
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