Related Experiment Video
Updated: Aug 13, 2026

Ovarian Tissue Culture to Visualize Phenomena in Mouse Ovary
Published on: June 19, 2018
Genetics of early mammalian folliculogenesis
1Department of Obstetrics and Gynecology, Baylor College of Medicine, Faculty Center, 1709 Dryden Street, Suite 1100, Houston 77030, USA.
Abstract:
Early ovarian folliculogenesis begins with the breakdown of germ cell clusters and formation of primordial follicles. Primordial follicles are the smallest ovarian follicle units continuously recruited to grow into primary and more advanced ovarian follicles. Genes expressed in the germ cells such as Figla, Nobox, Kit and Ntrk2, as well as genes expressed in the surrounding somatic cells such as Foxl2, Kitl and Ngf, play critical functions during early folliculogenesis. Transgenic mice continue to provide important insights into the genetic pathways that regulate early mammalian folliculogenesis. Genes critical in early folliculogenesis are important determinants of reproductive life span and represent candidate genes for human ovarian failure.
Related Concept Videos
Folliculogenesis
Oogenesis
Each primary oocyte is surrounded by a layer of pre-granulosa cells, forming what is known...
Oogenesis
Ovarian Cycle
Nondisjunction
