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Updated: Aug 13, 2026
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Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
Published on: May 26, 2021
[Ocular manifestations in bone marrow transplantation--case report]
Ewa Karwacka1, Urszula Ołdakowska-Jedynak, Leszek Paczek
1Z Kliniki Okulistyki Akademii Medycznej w Warszawie.
Klinika Oczna
|January 19, 2006
Summary
Two patients developed dry eyes and pemphigoid-like symptoms following bone marrow transplants. Immunosuppressive therapy improved their graft-versus-host disease (GVHD) symptoms.
Area of Science:
- Immunology
- Ophthalmology
- Dermatology
Background:
- Allogeneic bone marrow transplantation (BMT) can lead to complications.
- Graft-versus-host disease (GVHD) is a significant post-transplant concern.
Observation:
- Two patients presented with severe dry eyes (keratitis sicca) and pemphigoid-like skin manifestations post-BMT.
- Skin biopsies confirmed histopathological features consistent with GVHD.
Findings:
- The observed ocular and dermatological symptoms were indicative of GVHD.
- Systemic and local immunosuppressive treatments were initiated for both patients.
Implications:
- Early recognition and management of GVHD-related ocular and skin complications are crucial.
- Immunosuppression can effectively manage these debilitating post-BMT symptoms.
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