Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Medications for migraine prophylaxis.

Seema Modi1, Dionne M Lowder

  • 1Department of Family Medicine, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27834, USA. modis@mail.ecu.edu

American Family Physician
|January 19, 2006
PubMed
Summary

Several medications are recommended for migraine prevention, with propranolol and topiramate being top choices. Other drugs show fair effectiveness, while some have limited evidence or mixed reviews for managing migraines.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perspectives of community members regarding tube feeding in patients with end-stage dementia: findings from African-American and Caucasian focus groups.

Omega·2010
Same author

Clinical inquiries. When should you admit a patient with suspected CAP?

The Journal of family practice·2008
Same author

Which late-stage Alzheimer's patients should be referred for hospice care?

The Journal of family practice·2005
Same author

Clinical inquiries: Do statins delay onset or slow progression of Alzheimer's dementia?

The Journal of family practice·2005

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Migraine is a common neurological disorder impacting millions globally.
  • Effective migraine prevention strategies are crucial for improving patient quality of life.

Purpose of the Study:

  • To review and synthesize the evidence for various pharmacological agents used in migraine prevention.
  • To provide guidance on the selection of appropriate preventive medications based on efficacy and evidence levels.

Main Methods:

  • Systematic review of existing literature and clinical trial data.
  • Evaluation of evidence strength for each agent based on consensus and study findings.

Main Results:

  • First-line agents with sufficient evidence include propranolol, timolol, amitriptyline, divalproex, sodium valproate, and topiramate.
  • Gabapentin, naproxen sodium, and botulinum toxin show fair effectiveness, with further research needed for botulinum toxin.
  • Limited evidence supports candesartan, lisinopril, atenolol, metoprolol, nadolol, fluoxetine, magnesium, vitamin B2 (riboflavin), coenzyme Q10, and hormone therapy.
  • Verapamil and feverfew have mixed evidence and may be considered when other options fail.
  • Timed-release dihydroergotamine mesylate is supported by evidence but requires close monitoring for side effects.

Conclusions:

  • A range of medications offer effective migraine prevention, categorized by evidence strength.
  • Selection of preventive therapy should be guided by robust evidence and individual patient factors.
  • Ongoing research is vital to further define the roles of emerging and less-studied agents in migraine management.

Related Experiment Videos