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[Mast cells as a source of nitric oxide in the human placenta--morphometric analysis in preeclampsia complicated
Grzegorz Szewczyk1, Dariusz Szukiewicz, Wacław Smiertka
1Katedra i Zakład Patologii Ogólnej i Doświadczalnej AM w Warszawie.
Unlabelled:
The aim of the study was to test hypothesis, that in placenta mast cells are significant source of iNOS.
Material:
Placentas were collected after term delivery from healthy (control, n=13) and preeclamptic (n=11) women. Mast cells and iNOS expression were detected in obtained samples with monoclonal anti-iNOS and anti-tryptase antibodies. Next, morphometric analysis were performed. There were no significant difference between iNOS expression and number of iNOS-positive cells in normal and preeclamptic placentas. There was a significant increase in mast cells number in preeclamptic placentas (8.32 +/- 1.3 SD vs 5.14 +/- 1.2 SD in control) and decrease in percentage of iNOS positive cells among them (68.1% vs 23.6%). We conclude, that in uncomplicated pregnancies, mast cells are the main source of iNOS in placenta while in preeclampsia they loss their potential to synthetase iNOS.
