Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Generic bioaffinity silicone surfaces.

Hong Chen1, Michael A Brook, Heather D Sheardown

  • 1Department of Chemical Engineering, McMaster University, 1280 Main Street W., Hamilton ON Canada, L8S 4M1.

Bioconjugate Chemistry
|January 19, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Block copolymer synthesis using free-radical polymerization and thiol-maleimide 'click' conjugation.

RSC advances·2022
Same author

The effect of elastomer chain flexibility on protein adsorption.

Biomaterials·2013
Same author

Rapid and efficient assembly of functional silicone surfaces protected by PEG: cell adhesion to peptide-modified PDMS.

Journal of biomaterials science. Polymer edition·2010
Same author

Biocompatible, hyaluronic acid modified silicone elastomers.

Biomaterials·2010
Same author

Effect of delivery of MMP inhibitors from PDMS as a model IOL material on PCO markers.

Biomaterials·2009
Same author

Attenuation of lipopolysaccharide-mediated left ventricular dysfunction by glutamine preconditioning.

The Journal of surgical research·2009
Same journal

Neutral Amphiphiles Boost Transfection Efficiency and Reduce Inflammation in Polymer Micelle-Mediated mRNA Delivery.

Bioconjugate chemistry·2026
Same journal

Surfactant-Mediated Buchwald-Hartwig Coupling of Aliphatic Amines for the Synthesis of DNA-Encoded Libraries.

Bioconjugate chemistry·2026
Same journal

Artificial Intelligence for Discovery in Life Sciences.

Bioconjugate chemistry·2026
Same journal

Iron Single Atom Nanozyme-Mediated GPX4 Inhibitor Delivery for Self-Enhanced Ferroptosis.

Bioconjugate chemistry·2026
Same journal

SpyCatcher-Engineered Ferritin Nanocages Enable Dual-Receptor Targeting for Enhanced Glioma Therapy.

Bioconjugate chemistry·2026
Same journal

One-Pot Synthesis of Functionalized Coumarin Fluorophores Enables Rapid Access to Live-Cell Bioorthogonal Labeling and Microenvironmental Sensing Agents.

Bioconjugate chemistry·2026
See all related articles

This study presents a new method to make synthetic polymer surfaces biocompatible. The technique enhances silicone elastomers by attaching biological molecules, improving cell adhesion and preventing blood clots.

Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Polymer Science

Background:

  • Synthetic polymer surfaces often lack biocompatibility, limiting their use in biomedical applications.
  • Surface modification is crucial for improving the interaction of synthetic materials with biological systems.

Purpose of the Study:

  • To develop a versatile method for creating biocompatible silicone elastomers.
  • To functionalize silicone surfaces with various biomolecules for enhanced biological performance.

Main Methods:

  • A generic route involving hydrosilylation to graft poly(ethylene oxide) (PEO) onto silicone surfaces.
  • One-step covalent modification of the functionalized surfaces with amine-containing biomolecules.
  • Attachment of oligopeptides (YIGSR, RGDS), proteins (EGF, albumin, fibrinogen, mucin), and glycosaminoglycans (heparin).

Related Experiment Videos

Main Results:

  • High-density binding of biomolecules, such as 0.2 EGF molecules/nm², was achieved.
  • Demonstrated biocompatibility through thrombosis suppression with heparin + ATIII.
  • Promoted confluent corneal epithelial cell layer formation on surfaces modified with EGF, RGDS, or YIGSR.

Conclusions:

  • The described surface functionalization method provides a generic and efficient route to biocompatible silicone elastomers.
  • This approach enables tailored surface properties for specific biomedical applications, enhancing cell interactions and preventing adverse biological responses.