Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gephyrin: does splicing affect its function?

I Paarmann1, T Saiyed, B Schmitt

  • 1Department of Neurochemistry, Max-Planck-Institute for Brain Research, Deutschordenstrasse 46, D-60528 Frankfurt, Germany. paarmann@mpih-frankfurt.mpg.de

Biochemical Society Transactions
|January 19, 2006
PubMed
Summary

Gephyrin protein anchors inhibitory ion channels and aids cofactor synthesis. Its diverse functions, influenced by alternative splicing, are still being uncovered, particularly regarding binding partner interactions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of ferric hydroxysulfate on Mars and implications of the geochemical environment supporting its formation.

Nature communications·2025
Same author

Multi-disciplinary mass burn casualty simulation exercise.

Burns : journal of the International Society for Burn Injuries·2024
Same author

Multicenter Clinical Evaluation of the Revogene Strep A Molecular Assay for Detection of Streptococcus pyogenes from Throat Swab Specimens.

Journal of clinical microbiology·2020
Same author

Color, composition, and thermal environment of Kuiper Belt object (486958) Arrokoth.

Science (New York, N.Y.)·2020
Same author

A multicenter evaluation of a sample to answer real-time PCR assay for toxigenic C. difficile in symptomatic subjects.

Diagnostic microbiology and infectious disease·2019
Same author

Detection of ammonia on Pluto's surface in a region of geologically recent tectonism.

Science advances·2019

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biochemistry

Background:

  • Gephyrin is a crucial protein involved in inhibitory neurotransmission.
  • It plays a dual role in anchoring ligand-gated ion channels at synapses and in molybdenum cofactor synthesis.
  • Recent research has elucidated gephyrin's gene and protein structures, alongside identifying numerous binding partners.

Purpose of the Study:

  • To explore the functional diversity of gephyrin.
  • To investigate the mechanisms underlying gephyrin's interactions with its binding partners.
  • To understand the role of alternative splicing in gephyrin's cellular and tissue-specific functions.

Main Methods:

  • Literature review and analysis of existing research on gephyrin.
  • Bioinformatic analysis of gephyrin gene and protein sequences.

Related Experiment Videos

  • Comparative analysis of gephyrin expression and function across different cell types and tissues.

    • Main Results:

    • Gephyrin's structural characteristics are well-defined.
    • A significant number of gephyrin-interacting proteins have been identified.
    • The precise mechanisms of these interactions remain largely undetermined.
    • Alternative splicing is implicated as a key factor in gephyrin's functional variability.

    Conclusions:

    • Gephyrin's multifaceted roles in synaptic function and cofactor metabolism are established.
    • Further research is needed to elucidate the molecular mechanisms of gephyrin interactions.
    • Alternative splicing represents a critical mechanism for gephyrin's functional diversification.