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Updated: Aug 13, 2026

Visual Detection of Multiple Nucleic Acids in a Capillary Array
Published on: November 15, 2017
Nanotechnologies for biomolecular detection and medical diagnostics
Mark Ming-Cheng Cheng1, Giovanni Cuda, Yuri L Bunimovich
1Division of Hematology and Oncology, Internal Medicine, The Ohio State University, 473 West 12 Avenue, Columbus OH 43210-1002, USA.
Abstract:
Nanotechnology-based platforms for the high-throughput, multiplexed detection of proteins and nucleic acids in heretofore unattainable abundance ranges promise to bring substantial advances in molecular medicine. The emerging approaches reviewed in this article, with reference to their diagnostic potential, include nanotextured surfaces for proteomics, a two-particle sandwich assay for the biological amplification of low-concentration biomolecular signals, and silicon-based nanostructures for the transduction of molecular binding into electrical and mechanical signals, respectively.
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