Related Experiment Videos
Comparison of ondansetron and meperidine for prevention of shivering in patients undergoing spinal anesthesia
Ebru Kelsaka1, Sibel Baris, Deniz Karakaya
1Department of Anesthesiology, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey. ebruk@omu.edu.tr
Background And Objectives:
Perioperative hypothermia is a common problem in anesthesia practice. Regional anesthesia, like general anesthesia, influences the thermoregulatory process. The aim of our study was to compare the efficacy of ondansetron and meperidine in the prevention of shivering during and after spinal anesthesia.
Methods:
In this double-blind study, 75 patients were randomized into 3 groups. Group O and Group M were given ondansetron 8 mg and meperidine 0.4 mg/kg intravenously immediately before spinal anesthesia, respectively. Group C received saline at identical times. The core temperatures and the incidence of shivering were recorded. Association between maximum block height and mean rectal temperatures of the patients were also evaluated.
Results:
The core temperature was preserved in both ondansetron and meperidine groups with respect to the control group. Shivering was observed in 8% of patients in groups O and M and 36% in group C. The correlation between maximum block height and mean rectal temperatures was lost in the ondansetron and meperidine groups.
Conclusion:
Ondansetron and meperidine have similar anti-shivering effects. In addition, both ondansetron and meperidine altered the correlation between the core temperature and block level during spinal anesthesia.
Related Concept Videos
Peripherally and Centrally Acting Muscle Relaxants: A Comparison
Centrally acting muscle relaxants can be further divided into spasmolytic and antispasmodic drugs. Spasmolytic drugs,...
Local Anesthetics: Clinical Application as Spinal Anesthesia
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Skeletal Muscle Relaxants: Therapeutic Uses
Classification of Skeletal Muscle Relaxants
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Phenothiazines, such as prochlorperazine...