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Related Experiment Videos

Medication adherence and persistence: a comprehensive review.

Kem P Krueger1, Bruce A Berger, Bill Felkey

  • 1University of Wyoming, Laramie, 82071, USA.

Advances in Therapy
|January 19, 2006
PubMed
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Medication nonadherence is common and costly. Multifaceted interventions addressing individual patient barriers, supported by strong patient-provider relationships, are most effective for improving long-term medication adherence.

Area of Science:

  • Pharmacology
  • Health Services Research
  • Patient Adherence

Background:

  • Medication nonadherence, ranging from 17% to 80%, significantly increases morbidity, mortality, and healthcare costs.
  • Effective interventions require a multifaceted approach targeting specific patient barriers and reinforcing positive behaviors.

Purpose of the Study:

  • To describe barriers to medication adherence and persistence.
  • To identify and evaluate interventions and compliance aids for practitioners and organizations to improve adherence.

Main Methods:

  • Review of existing literature on medication adherence barriers and interventions.
  • Analysis of factors influencing patient adherence, including provider communication, patient understanding, and socioeconomic determinants.

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Main Results:

  • Provider-patient relationships, clear communication, and assessment of patient readiness are crucial for adherence.
  • Cognitive impairment, lack of support, financial difficulties, and fear of adverse effects are significant barriers.
  • Tailored solutions addressing individual patient needs are essential for successful adherence.

Conclusions:

  • Healthcare providers must understand and address diverse barriers to medication adherence.
  • Implementing targeted interventions and compliance aids can improve patient persistence with long-term medication regimens.