Related Experiment Video
Updated: Aug 13, 2026

Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma
Published on: January 19, 2024
Adverse reactions to permanent eyeliner tattoo
M Reza Vagefi1, Laryssa Dragan, Susan M Hughes
1Ophthalmic Plastic and Reconstructive Surgery, Department of Ophthalmology, University of California, San Francisco, 94110, USA.
Serious adverse reactions, including allergic granulomatous reactions, can occur after permanent eyeliner tattoos. Treatment may involve steroids or surgical removal of tattoo pigment.
Area of Science:
- Ophthalmology
- Dermatology
- Pathology
Background:
- Permanent eyeliner tattoos are increasingly popular cosmetic procedures.
- Adverse reactions to tattoo pigments can manifest in various ways.
- Understanding these reactions is crucial for patient safety and management.
Observation:
- A case series of 4 patients with inflammatory eyelid reactions post-eyeliner tattoo.
- Clinical presentation included firm, raised masses beneath the tattooed pigment.
- Histopathology revealed a granulomatous inflammatory response without infection.
Findings:
- Permanent eyeliner tattoos can trigger allergic granulomatous reactions.
- Treatment strategies included topical/local/systemic steroids and surgical excision.
- All reported cases showed successful outcomes with varied treatment approaches.
Implications:
- Ophthalmologists and dermatologists should be aware of potential severe reactions to permanent eyeliner.
- Management can be complex, sometimes necessitating removal of the tattoo pigment.
- Early diagnosis and appropriate treatment are key to resolving these inflammatory reactions.
Related Concept Videos
Healing II: Complications
Accessory Structures of the Eye
Cardiac Catheterization I: Pre-Procedure Overview
Cardiac Catheterization IV: Nursing Management
Local Anesthetics: Common Agents and Their Applications
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Angle Closure Glaucoma: Treatment