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Related Experiment Videos

Body fat and circulating leukocytes in children.

F Zaldivar1, R G McMurray, D Nemet

  • 1Pediatric Exercise Research Center, University of California, Irvine, CA, USA.

International Journal of Obesity (2005)
|January 19, 2006
PubMed
Summary
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Overweight children have higher circulating immune cell counts, indicating low-grade inflammation. This finding supports interventions to prevent and manage pediatric obesity.

Area of Science:

  • Pediatric Endocrinology
  • Immunology
  • Public Health

Background:

  • Obesity is a growing global health concern in children.
  • It is associated with various comorbidities, including chronic inflammation.
  • Understanding the immunological impact of pediatric obesity is crucial for early intervention.

Purpose of the Study:

  • To investigate the relationship between obesity and circulating immune cell levels in children.
  • To determine if overweight children exhibit altered granulocyte, monocyte, and lymphocyte counts.
  • To explore correlations between body composition metrics and immune cell populations.

Main Methods:

  • A comparative study design was used, analyzing leukocytes in normal weight (NW) and overweight (OW) children.
  • Participants included 38 children (ages 6-18), with 15 NW and 23 OW based on BMI percentiles.

Related Experiment Videos

  • Body mass index (BMI), body fat percentage (DEXA), and complete blood counts (CBC) with flow cytometry were assessed.

    • Main Results:

    • Overweight children showed significantly higher total leukocyte counts, neutrophils, monocytes, and T lymphocytes (CD3, CD4+).
    • Leukocyte counts positively correlated with BMI percentile, BMI, and percent body fat.
    • No significant relationships were found between lean body mass or VO2peak and leukocyte levels.

    Conclusions:

    • Overweight children exhibit elevated circulating immune cell counts, suggesting low-grade systemic inflammation.
    • This inflammation is a potential mechanism for obesity-related long-term health complications.
    • The findings underscore the importance of preventing and correcting pediatric obesity.