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Mycobacterium tuberculosis complex in atherosclerosis.

Simin Rota¹, Seyyal Rota

¹Department of Biochemistry, Pamukkale University Medical School, Denizli, Turkey. siminrota@yahoo.co.uk

Acta Medica Okayama

|January 19, 2006

Summary

Infectious agents may contribute to atherosclerosis. Mycobacterium tuberculosis shows potential links, with evidence including heat shock proteins and phospholipid effects, suggesting its role in disease development.

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Area of Science:

Cardiovascular Research
Infectious Diseases
Immunology

Background:

Atherosclerosis involves inflammation, with infectious agents increasingly implicated.
Studies have detected antibodies and genomic material of various pathogens in atherosclerotic patients.

Purpose of the Study:

To explore the potential role of Mycobacterium tuberculosis in the pathogenesis of atherosclerosis.
To review evidence linking mycobacterial components to atherosclerotic mechanisms.

Main Methods:

Review of existing studies on infectious agents and atherosclerosis.
Analysis of findings related to heat shock proteins (HSP65) and phospholipids in Mycobacterium tuberculosis and atherosclerosis.
Examination of animal model data.

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Main Results:

Elevated levels of mycobacterial heat shock protein 65 (HSP65) found in atherosclerotic patients.
Animal studies showed vascular changes after vaccination with HSP65 or Mycobacterium tuberculosis.
Mycobacterium tuberculosis contains phosphatidylinositol, a phospholipid with procoagulant effects, similar to phosphatidylserine in cytomegalovirus.

Conclusions:

Evidence suggests Mycobacterium tuberculosis may play a role in atherosclerosis development.
The immune response to mycobacterial HSP65 and its cell wall components may be proatherogenic.
Further research is warranted to confirm the involvement of Mycobacterium tuberculosis in atherosclerosis pathogenesis.