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Chiari I malformation and idiopathic growth hormone deficiency in siblings
R L Murphy1, R S Tubbs, P A Grabb
1School of Medicine, University of Alabama, Birmingham, AL 35233, USA.
Introduction:
The authors report a case of three brothers. Two of these siblings presented with congenital growth hormone deficiency and Chiari I malformation. The third and younger brother has been found not to have growth hormone deficiency or the Chiari I malformation.
Results:
Sparse cases of these two clinical occurrences have been reported. Further, the posterior cranial fossa has been determined to be altered in patients with Chiari I malformation and growth hormone deficiency.
Conclusion:
Our current case reports strengthen the association between these two pathological entities and are, to our knowledge, the first description of both defects in siblings.
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