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Obstetrical antiphospholipid syndrome.

Serena Wu1, Mary D Stephenson

  • 1Section of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Chicago, Chicago, Illinois 60637, USA.

Seminars in Reproductive Medicine
|January 19, 2006
PubMed
Summary
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Antiphospholipid syndrome (APS) is an autoimmune disorder affecting pregnancy. Treatment with aspirin and heparin improves live birth rates but maternal and fetal complications persist, requiring further research.

Area of Science:

  • Obstetrics and Gynecology
  • Immunology
  • Hematology

Background:

  • Antiphospholipid syndrome (APS) is an autoimmune condition linked to blood clots and pregnancy complications.
  • Obstetrical APS features include recurrent miscarriage, fetal death, preeclampsia, and growth restriction.
  • Understanding APS pathophysiology and antibody associations is crucial for managing obstetrical cases.

Purpose of the Study:

  • To review obstetrical morbidity in Antiphospholipid syndrome (APS).
  • To discuss diagnostic criteria limitations for obstetrical APS.
  • To appraise current treatment trials and suggest future research directions.

Main Methods:

  • Literature review of obstetrical APS.
  • Analysis of diagnostic criteria and their limitations.

Related Experiment Videos

  • Appraisal of clinical trials on APS treatment in pregnancy.

    • Main Results:

    • Obstetrical APS encompasses miscarriage, fetal demise, preeclampsia, and growth restriction.
    • Low-dose aspirin and heparin show 70-80% live birth rates in small trials.
    • Despite treatment, significant maternal and fetal morbidity remains in APS pregnancies.

    Conclusions:

    • Obstetrical APS presents significant risks to both mother and fetus.
    • Current diagnostic criteria and treatments have limitations.
    • Further research is essential to improve outcomes for pregnant individuals with APS.