Related Experiment Video
Updated: Aug 13, 2026
09:17
In Vivo Luminal Measurement of Distension-Evoked Urothelial ATP Release in Rodents
Published on: September 7, 2022
Maximal urethral closure pressure < 20 cm H2O: does it predict intrinsic sphincteric deficiency?
Haim Krissi1, Mordechay Pansky, Reuvit Halperin
1Department of Obstetrics and Gynecology, Rabin Medical Center, Petah-Tikva, Israel. haimkrissi@hotmail.com
The Journal of Reproductive Medicine
|January 20, 2006
Summary
Measuring maximal urethral closure pressure (MUCP) in the supine position, not sitting, is crucial for accurately diagnosing intrinsic sphincteric deficiency (ISD). This standardized method impacts diagnostic criteria for ISD.
Area of Science:
- Urology
- Female Pelvic Medicine
Background:
- The incidence of intrinsic sphincteric deficiency (ISD) varies significantly in medical literature.
- This discrepancy may stem from differing methodologies in measuring maximal urethral closure pressure (MUCP).
Purpose of the Study:
- To investigate if variations in MUCP measurement techniques contribute to the inconsistent ISD incidence reported in studies.
- To compare MUCP measurements obtained in supine versus sitting positions.
Main Methods:
- Maximal urethral closure pressure (MUCP) was measured in 54 women with stress urinary incontinence.
- Measurements were taken in the supine position (300 mL saline) and sitting position (full bladder), following International Continence Society guidelines.
Main Results:
- Mean MUCP was significantly higher in the supine position (38.4 cm H2O) compared to the sitting position (22.8 cm H2O).
- A MUCP ≤ 20 cm H2O was observed in 25.9% of patients in the sitting position versus only 1.8% in the supine position.
Conclusions:
- The diagnostic cutoff for ISD when measuring MUCP in the supine position should be 35 cm H2O, not 20 cm H2O.
- Standardizing MUCP measurement to the supine position is essential for consistent ISD diagnosis.
Related Concept Videos
01:19Urodynamic Studies: Uroflowmetry
Uroflowmetry is a non-invasive urodynamic test designed to measure various aspects of urination, including volume, flow rate, and the time to void. This test is crucial for diagnosing and assessing conditions such as bladder outlet obstruction, bladder dysfunction, incomplete bladder emptying, incontinence, and urinary tract blockages caused by benign prostatic hyperplasia (BPH) and urethral strictures.Pre-Test Instructions:Before a uroflowmetry test, patients are typically advised to drink...
01:26The Micturition Reflex
Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating urine...
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating urine...
01:19Anatomy of the Genitourinary System II: Bladder and Urethra
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...