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Specific changes in conditioned responding following neurotoxic damage to the posterior parietal cortex
1Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755, USA. david.j.bucci@dartmouth.edu
Behavioral Neuroscience
|January 20, 2006
Summary
Lesions to the posterior parietal cortex (PPC) did not impair orienting behaviors. However, damage to the PPC did disrupt food cup behaviors, suggesting specific roles in associative learning.
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Behavioral Neuroscience
Background:
- The central nucleus (CN) of the amygdala and basal forebrain cholinergic projections to the posterior parietal cortex (PPC) regulate attentional processing of conditioned stimuli.
- Previous research showed CN lesions impair conditioned orienting behavior but not unconditioned orienting or food cup behavior.
Purpose of the Study:
- To investigate the role of the posterior parietal cortex (PPC) in attentional orienting behavior.
- To elucidate the specific contributions of the PPC to associative learning.
Main Methods:
- Lesions were induced in the posterior parietal cortex (PPC) of subjects.
- Subjects were tested on conditioned orienting behavior (rearing) and food cup behavior.
Main Results:
- Damage to the PPC did not affect orienting behavior.
- Deficits were observed in food cup behavior following PPC damage.
Conclusions:
- The posterior parietal cortex (PPC) plays a specific role in associative learning, particularly in behaviors like food cup engagement.
- These findings differentiate the functional contributions of the PPC and the central nucleus (CN) in attentional processing and learning.

