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Published on: December 11, 2020
Aging and oxidative stress in progressive supranuclear palsy
K Aoyama1, K Matsubara, S Kobayashi
1Department of Internal Medicine III, School of Medicine, Shimane University, Izumo, Japan. kaoyama@itsa.ucsf.edu
European Journal of Neurology
|January 20, 2006
Summary
Progressive supranuclear palsy (PSP) involves oxidative stress. In aging PSP patients, the antioxidant system shows increased Cu/Zn-superoxide dismutase (SOD) and glutathione peroxidase (GPx), but HNE-conjugation may impair function.
Area of Science:
- Neuroscience
- Biochemistry
Background:
- Progressive supranuclear palsy (PSP) is a neurodegenerative disease potentially linked to oxidative stress.
- The impact of aging on the endogenous antioxidant system in PSP is not fully understood.
Purpose of the Study:
- To investigate age-related changes in the antioxidant system in PSP patients.
- To assess levels of Cu/Zn-superoxide dismutase (SOD), glutathione peroxidase (GPx), and 4-hydroxynonenal (HNE)-conjugated GPx in PSP cerebrospinal fluid.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure antioxidant markers in cerebrospinal fluid.
- Cu/Zn-SOD, GPx, and HNE-conjugated GPx levels were quantified in PSP patients and control groups.
Main Results:
- PSP patients exhibited significantly elevated Cu/Zn-SOD levels compared to controls.
- Cu/Zn-SOD and GPx levels positively correlated with age in the PSP group.
- Two-thirds of total GPx in PSP patients was HNE-conjugated, also showing a positive correlation with age.
Conclusions:
- The endogenous antioxidant system in PSP patients appears activated with aging.
- However, HNE-conjugation of GPx may compromise its effective function in aging PSP patients.
- These findings suggest a potential mechanism for oxidative stress in PSP progression.
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