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Mobius syndrome with basal ganglia calcification
B Singh1, S A Shahwan, P Singh
1Department of Paediatrics, Riyadh Armed Forces Hospital, Saudi Arabia.
Acta Neurologica Scandinavica
|June 1, 1992
Summary
Basal ganglia calcification is a newly observed symptom in Mobius syndrome. This finding in two siblings suggests a potential link between the syndrome and cerebral involvement.
Area of Science:
- Neurology
- Genetics
- Pediatrics
Background:
- Mobius syndrome is a rare congenital neurological disorder.
- Cerebral involvement is not a commonly described feature of Mobius syndrome.
Observation:
- A family with two affected children with Mobius syndrome was studied.
- Computed tomography (CT) scans were performed on both children.
Findings:
- Bilateral basal ganglia calcification was identified in both children via CT scans.
- This represents the first documented instance of basal ganglia calcification in Mobius syndrome.
Implications:
- The findings suggest a potential association between Mobius syndrome and basal ganglia calcification.
- Further research is needed to explore the underlying mechanisms and genetic factors.
- This discovery may impact the diagnostic criteria and management of Mobius syndrome.