Neuronal activity related to elapsed time in prefrontal cortex
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Updated: Aug 13, 2026

Performing Behavioral Tasks in Subjects with Intracranial Electrodes
Published on: October 2, 2014
Aldo Genovesio1, Satoshi Tsujimoto, Steven P Wise
1Laboratory of Systems Neuroscience, National Institute of Mental Health, Building 49, Room B1EE17, 49 Convent Drive, MSC 4401, Bethesda, MD 20892-4401, USA.
Abstract:
We studied prefrontal cortex activity during a saccade task. On each trial, one of three delay periods elapsed between the onset of a visual stimulus and its offset, which triggered a saccade. After stimulus offset, many neurons showed phasic increases in activity that depended on the duration of the preceding delay period. This delay-dependent activity varied only weakly with reaction time and instead appeared to reflect a more general aspect of elapsed time.
