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Related Experiment Videos

CNS microvascular pericytes exhibit multipotential stem cell activity.

Paula Dore-Duffy1, Andre Katychev, Xueqian Wang

  • 1Department of Neurology, Division of Neuroimmunology, Multiple Sclerosis Clinical Research Center, Wayne State University School of Medicine, Detroit Medical Center, Detroit, Michigan 48201, USA. pdduffy@med.wayne.edu

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|January 20, 2006
PubMed
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Adult central nervous system (CNS) pericytes, a type of microvascular cell, can differentiate into neural stem cells. These pericytes express specific markers and show multipotent regenerative potential.

Area of Science:

  • Neuroscience
  • Stem Cell Biology
  • Vascular Biology

Background:

  • The identity of multipotent stem/progenitor cells with vascular and mesenchymal relationships has been unclear.
  • Adult central nervous system (CNS) capillaries harbor microvascular cells known as pericytes.

Purpose of the Study:

  • To identify and characterize a specific population of microvascular cells within the adult CNS.
  • To investigate the differentiation potential of CNS pericytes.

Main Methods:

  • Isolation and culture of primary adult CNS pericytes.
  • Induction of differentiation using basic fibroblast growth factor (bFGF).
  • Characterization of cell markers using immunocytochemistry, including nestin, NG2, alphaSMA, and GSA.

Related Experiment Videos

Main Results:

  • Adult CNS pericytes express nestin and NG2 proteoglycan in their microvascular location.
  • In bFGF-containing media, pericytes formed spheres that differentiated into neural lineage cells, expressing neuronal and glial markers.
  • Differentiated spheres demonstrated self-renewal capacity and generated pericyte, neuron, and glial cell populations.

Conclusions:

  • Adult CNS microvascular pericytes possess neural stem cell capabilities.
  • Pericytes represent a potential source for neural stem cells derived from the CNS vasculature.