Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Is tropical pancreatitis premalignant?

P Augustine1, H Ramesh

  • 1Department of Gastroenterology, Deva Matha Hospital, Koothattukulam, Kerala, India.

The American Journal of Gastroenterology
|August 1, 1992
PubMed
Summary

Tropical pancreatitis significantly increases pancreatic cancer risk. Cancers in tropical pancreatitis patients differ from de novo cancers, presenting earlier and with distinct characteristics, suggesting an etiological link.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of stakeholder knowledge and practices of water use management strategy: Observations from a questionnaire survey in Southern India.

Heliyon·2024
Same author

Impact of Covid-19 on gastrointestinal cancer surgery: A National Survey.

Langenbeck's archives of surgery·2022
Same author

Increasing the exclusive breastfeeding rate in a private hospital in UAE through quality improvement initiatives.

Journal of neonatal-perinatal medicine·2021
Same author

Exploring the relationship between LST and land cover of Bengaluru by concentric ring approach.

Environmental monitoring and assessment·2020
Same author

An Unusual Cause of Chylothorax after Esophagectomy.

Surgery journal (New York, N.Y.)·2020
Same author

Pubertal Menorrhagia - A Rare Presentation of Congenital Factor XIII Deficiency.

Indian pediatrics·2020

Area of Science:

  • Gastroenterology
  • Oncology
  • Epidemiology

Background:

  • Tropical pancreatitis is a chronic inflammatory condition of the pancreas.
  • Pancreatic cancer is a leading cause of cancer-related mortality worldwide.
  • Understanding risk factors and distinct characteristics of pancreatic cancer in specific populations is crucial for early detection and treatment.

Observation:

  • Pancreatic adenocarcinoma developed in 8.3% of patients with tropical pancreatitis over an 8-year period.
  • A comparison was made between benign tropical pancreatitis, tropical pancreatitis with superimposed malignancy, and de novo pancreatic cancer.
  • Risk factors for malignancy in tropical pancreatitis included age > 40, short symptom duration, weight loss, ultrasound mass, and ductal obstruction.

Findings:

Related Experiment Videos

  • Pancreatic cancers associated with tropical pancreatitis occurred in younger patients (mean age 47 vs. 61 years) compared to de novo cancers.
  • All tropical pancreatitis-associated cancers had calculi, unlike de novo cancers.
  • Higher rates of diabetes (73% vs. 24%) and tumors in the pancreatic body and tail (73% vs. 34%) were observed in the tropical pancreatitis cancer group.
  • Survival was significantly poorer for patients with malignancy in tropical pancreatitis (10 months) compared to de novo cancer (17 months).
  • Dysplastic changes were noted alongside cancer in resected specimens from the tropical pancreatitis group.

    • Implications:

    • Tropical pancreatitis is strongly associated with an increased risk of pancreatic cancer.
    • Malignancy arising in the context of tropical pancreatitis exhibits unique clinical and pathological features compared to de novo pancreatic cancer.
    • The findings suggest a potential etiological relationship between tropical pancreatitis and pancreatic cancer, warranting further investigation, especially considering the low incidence of pancreatic cancer in regions like southern India.