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[Abnormalities of haemostasis in myocardial infarction with normal coronary artery]

Hassine Mohsen1, Addad Faouzi, Ben Hamda Khaldoun

  • 1Laboratoire d'hématologie, E.P.S Fattouman Bourguiba de Monastír.

La Tunisie Medicale
|January 21, 2006
PubMed

Insights

Myocardial infarction with normal coronary arteries is linked to hemostasis abnormalities. Antiphospholipid antibodies were most common, suggesting further investigation for affected patients.

Area of Science:

  • Cardiology
  • Hematology
  • Internal Medicine

Background:

  • Myocardial infarction (MI) with normal coronary arteries (MINCA) presents similarly to atheromatous MI.
  • Hemostasis abnormalities are increasingly implicated in the pathogenesis of MINCA.

Purpose of the Study:

  • To investigate hemostasis abnormalities in patients diagnosed with MI and angiographically normal coronary arteries.

Main Methods:

  • Thirty-nine patients (33 males, 6 females; age 22-75) with MINCA were studied.
  • Assessed for deficiencies in protein C, protein S, and antithrombin.
  • Evaluated for activated protein C resistance and antiphospholipid antibodies.

Main Results:

  • Ten patients (25.6%) exhibited concurrent hemostasis abnormalities.
  • Antiphospholipid antibodies were the most frequent finding (5 patients).
  • Other abnormalities included protein C deficiency (2), protein S deficiency (2), antithrombin deficiency (2), and activated protein C resistance (3).

Conclusions:

  • High prevalence of hemostasis abnormalities in MINCA patients suggests routine screening.
  • Screening is particularly recommended for younger patients with MINCA.
  • Identifying these abnormalities can significantly impact patient management strategies.
Abstract

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