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Testosterone deficiency as a risk factor for hip fractures in men: a case-control study
J A Jackson1, M W Riggs, A M Spiekerman
1Department of Medicine, Scott & White Clinic, Scott & White Memorial Hospital, Scott, Sherwood and Brindley Foundation, Texas A&M University College of Medicine, Temple 76508.
The American Journal of the Medical Sciences
|July 1, 1992
Summary
Low testosterone levels are a significant risk factor for hip fractures in elderly men. This study found that testosterone deficiency was prevalent in men with hip fractures, suggesting it
Area of Science:
- Gerontology
- Endocrinology
- Orthopedics
Background:
- Hip fractures are a major health concern in elderly populations, particularly men.
- The role of gonadal function, specifically testosterone levels, in hip fracture risk is not well-established.
- Vitamin D deficiency is a known risk factor for bone health and fractures.
Purpose of the Study:
- To investigate the association between decreased gonadal function (testosterone levels) and hip fracture risk in elderly men.
- To determine if testosterone deficiency is an independent risk factor for hip fractures.
Main Methods:
- A matched case-control study design was employed.
- Participants included elderly men with hip fractures (cases) and age-, race-, and living status-matched controls.
- Serum levels of total testosterone, free testosterone, and 25-hydroxyvitamin D were measured.
Main Results:
- Hip fracture patients exhibited significantly lower serum levels of total and free testosterone compared to controls.
- Testosterone deficiency was diagnosed in 71% of hip fracture patients versus 32% of controls (odds ratio 5.3).
- Serum 25-hydroxyvitamin D levels were also significantly lower in the hip fracture group.
Conclusions:
- Decreased gonadal function (testosterone deficiency) is an important, understudied risk factor for hip fractures in elderly men.
- Early recognition and treatment of testosterone deficiency may aid in the prevention of hip fractures in men.
- Further research is warranted to elucidate the precise mechanisms linking testosterone deficiency to hip fracture risk.