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Related Experiment Videos

Meibomian gland function and giant papillary conjunctivitis.

W D Mathers1, M Billborough

  • 1Center for Sight, Georgetown University Medical Center, Washington, D.C.

American Journal of Ophthalmology
|August 15, 1992
PubMed
Summary

Giant papillary conjunctivitis (GPC) in contact lens wearers is linked to meibomian gland dysfunction (MGD). Patients with GPC showed significantly more meibomian gland dropout and thicker secretions, indicating a connection between these conditions.

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Area of Science:

  • Ophthalmology
  • Contact Lens Science
  • Ocular Surface Disease

Background:

  • Giant papillary conjunctivitis (GPC) is an inflammatory condition affecting the conjunctiva.
  • Meibomian gland dysfunction (MGD) involves abnormalities of the meibomian glands, impacting tear film stability.
  • Contact lens wear is a known risk factor for both GPC and MGD.

Purpose of the Study:

  • To investigate the association between clinical signs of GPC and the presence and severity of MGD, specifically meibomian gland dropout, in contact lens wearers.
  • To compare meibomian gland function and ocular surface parameters between contact lens wearers with and without GPC.

Main Methods:

  • A cohort of 42 contact lens wearers was evaluated for clinical GPC.
  • Meibomian gland dropout was assessed, and meibomian gland excreta viscosity was measured.

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  • Tear osmolarity and Schirmer test results were recorded for comparison.

    • Main Results:

    • Twenty-seven patients exhibited clinical GPC, while 15 did not.
    • Patients with GPC demonstrated significantly higher rates of meibomian gland dropout (0.6 +/- 1.2 absent glands) compared to those without GPC (0.2 +/- 0.4 absent glands).
    • Meibomian gland excreta viscosity was notably greater in the GPC group; tear osmolarity and Schirmer test results showed no significant differences between groups.

    Conclusions:

    • Contact lens wearers diagnosed with GPC are more prone to meibomian gland dysfunction, characterized by gland dropout.
    • Increased viscosity of meibomian gland secretions may be an associated factor in GPC development in this population.
    • These findings highlight the interconnectedness of GPC and MGD in the context of contact lens wear, suggesting potential targets for management.