Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Physiology of erectile function.

Iñigo Sáenz de Tejada1, Javier Angulo, Selim Cellek

  • 1Fundacion para la Investigacion y el Desarrollo en Andrologia, Madrid, Spain. isdtejada@terra.es

The Journal of Sexual Medicine
|January 21, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of a non-invasive oestrous synchronisation protocol on sexual behaviour in Sprague-Dawley rats.

The journal of sexual medicine·2026
Same author

Combination therapy for acute Peyronie' s disease: a success story of translation from bench to bedside.

Nature reviews. Urology·2026
Same author

Senicapoc in Patients with Idiopathic Pulmonary Fibrosis or Other Progressive Fibrotic Interstitial Lung Diseases: Protocol for a Randomised, Double-Blind, Placebo-Controlled, Multicentre Phase II Trial.

Diagnostics (Basel, Switzerland)·2026
Same author

Gender Differences in Circulating TFAM Levels Are Associated with Functional Impairment and Sarcopenia.

Biomedicines·2026
Same author

Support, Monitoring, and Reminder Technology for Mild Dementia (SMART4MD) for People With Mild Cognitive Impairment and Their Informal Caregivers: Cost-Effectiveness Analysis.

JMIR human factors·2026
Same author

Evaluation of a combination of off-label PDE5 inhibitor and tamoxifen in acute Peyronie's disease.

The journal of sexual medicine·2026

Understanding penile smooth muscle tone is key to erectile function. New insights into the molecular mechanisms regulating this tone offer potential targets for treating erectile dysfunction.

Area of Science:

  • Urology
  • Sexual Medicine
  • Physiology

Background:

  • Penile smooth muscle tone, regulated by relaxant and contractile factors, determines penile flaccidity or erection.
  • Enhanced understanding of erectile physiology can improve the management of erectile dysfunction.
  • This review focuses on the state-of-the-art knowledge regarding erectile function physiology.

Purpose of the Study:

  • To provide comprehensive, up-to-date knowledge on the physiology of erectile function.
  • To consolidate expert opinion on the mechanisms underlying erectile function.

Main Methods:

  • An international consultation involving over 200 experts from 60 countries, organized into 17 committees.
  • Expert opinion was formed through grading evidence-based medical literature, internal discussions, and public debate over a two-year period.

Related Experiment Videos

  • A dedicated committee of seven experts from five countries focused on erectile function and dysfunction.

    • Main Results:

    • Penile smooth muscle tone is critically influenced by intracellular calcium concentration and contractile machinery sensitivity.
    • Endothelial health, nitric oxide (NO) pathways (endothelium-derived NO and neuronal NO), and endothelium-derived hyperpolarizing factor (EDHF) play significant roles.
    • Cyclic guanosine monophosphate-dependent protein kinase and phosphodiesterase type 5 are key molecular players.

    Conclusions:

    • New mechanisms for the local regulation of penile smooth muscle contractility and erection have been identified.
    • These newly identified molecular pathways represent potential therapeutic targets for novel erectile dysfunction treatments.