Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain blood flow and metabolism do not decrease at stable brain temperature during cardiopulmonary bypass in rabbits.

B J Hindman1, F Dexter, J Cutkomp

  • 1Department of Anesthesia, College of Medicine, University of Iowa, Iowa City.

Anesthesiology
|August 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Literature search for healthcare management decision-making on how to increase productivity by performing more surgical cases in the same staffed time.

Revista espanola de anestesiologia y reanimacion..·2024
Same author

The relative efficacy of multiple syringe tip disinfection techniques against virulent staphylococcus contamination.

The Journal of hospital infection·2024
Same author

Characterizing the molecular epidemiology of anaesthesia work area transmission of Staphylococcus aureus sequence type 5.

The Journal of hospital infection·2023
Same author

Transmission of Staphylococcus aureus in the anaesthesia work area has greater risk of association with development of surgical site infection when resistant to the prophylactic antibiotic administered for surgery.

The Journal of hospital infection·2023
Same author

American Society of Anesthesiologists' Relative Value Guide.

Anaesthesia·2022
Same author

Implications of variation by time of day in post-anaesthesia care unit length of stay for rational nurse staffing.

British journal of anaesthesia·2018
Same journal

The Time-out.

Anesthesiology·2026
Same journal

Evaluation of Post-block Hypersensitivity Using Quantitative Sensory Testing Before, During, and After Axillary Brachial Plexus Block Resolution in Healthy Volunteers.

Anesthesiology·2026
Same journal

The state of medical education research in Anesthesiology: Current landscape and future directions - An initiative of the Anesthesia Research Council.

Anesthesiology·2026
Same journal

Diagnostic Ultrasound-guided Focused Ultrasound-induced Noninvasive, Reversible Peripheral Nerve Blockade in an In Vivo Model of Acute Pain: A Proof-of-Concept Study.

Anesthesiology·2026
Same journal

S-Ketamine Reduces Risk of Postoperative Delirium: Comment.

Anesthesiology·2026
Same journal

Computed Tomography-Based Body Composition Assessment for Preoperative Cardiovascular Risk Prediction: A Prospective Cohort Study.

Anesthesiology·2026
See all related articles

Cerebral blood flow (CBF) remains stable during hypothermic cardiopulmonary bypass once brain temperature is constant. This suggests that initial CBF decreases are due to ongoing cooling, not vasoconstriction.

Area of Science:

  • Cardiovascular Physiology
  • Neuroscience
  • Surgical Research

Background:

  • Cerebral blood flow (CBF) may decrease during hypothermic cardiopulmonary bypass.
  • This reduction is hypothesized to be due to vasoconstriction or emboli.
  • Alternatively, progressive brain cooling could be responsible.

Purpose of the Study:

  • To test if reduced CBF during bypass is due to continued brain cooling.
  • To determine if CBF is stable after constant brain temperature is achieved.

Main Methods:

  • Rabbits underwent cardiopulmonary bypass with three management groups (normothermic, hypothermic pH-stat, hypothermic alpha-stat).
  • Cerebral cortical, esophageal, and perfusate temperatures were monitored.
  • CBF and cerebral metabolic rate for oxygen (CMRO2) were measured at intervals.

Related Experiment Videos

Main Results:

  • In normothermic animals, CBF was stable throughout bypass.
  • In hypothermic groups, brain temperature equilibration took approximately 41 minutes.
  • No significant changes in CBF were observed in normothermic animals between 30 and 90 minutes.

Conclusions:

  • Observed reductions in CBF during hypothermic cardiopulmonary bypass may be attributed to ongoing undetected brain cooling.
  • CBF appears stable once a constant brain temperature is achieved, irrespective of management strategy.