Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Longitudinal changes in insulin sensitivity, insulin secretion, and beta-cell function during puberty.

Geoff D C Ball1, Terry T-K Huang, Barbara A Gower

  • 1Department of Preventive Medicine, University of Southern California, Los Angeles, USA.

The Journal of Pediatrics
|January 21, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Use of Inhibin B in Male Adolescent Childhood Cancer Survivors: Correlation With Cyclophosphamide Equivalent Dosing.

Journal of pediatric hematology/oncology·2026
Same author

Prevalence of Metabolically Healthy Obesity in Canadian Children and Adolescents at Entry to Pediatric Weight Management Clinic and One Year Later: A Secondary Analysis of CANadian Pediatric Weight Management Registry Data.

Childhood obesity (Print)·2026
Same author

Greater reduction in the proinsulin-C-peptide ratio with a ketogenic vs control diet in patients with type 2 diabetes.

Journal of the Endocrine Society·2026
Same author

Exploring Canadian Registered Dietitians' Confidence, Facilitators, Barriers, and Resource Needs in Father Engagement.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2026
Same author

A new Canadian clinical practice guideline for managing obesity in children: Some tried, some true and some very new.

Paediatrics & child health·2026
Same author

Characterizing healthcare provider experiences delivering genomic testing in a Federally Qualified Health Center.

Communications medicine·2026

Puberty causes temporary insulin resistance and reduced insulin secretion in both white and black youth. Black youth showed a greater decline in beta-cell function, potentially increasing type 2 diabetes risk.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Health
  • Human Physiology

Background:

  • Puberty significantly alters metabolic processes, including glucose homeostasis.
  • Understanding racial differences in pubertal metabolic changes is crucial for identifying health risks.

Purpose of the Study:

  • To investigate longitudinal changes in insulin sensitivity (SI), insulin secretion, and beta-cell function during puberty.
  • To compare these changes between white and black youth.

Main Methods:

  • Utilized the tolbutamide-modified frequently sampled intravenous glucose tolerance test and minimal modeling.
  • Measured SI, acute insulin response to glucose (AIRg), and disposition index (DI) in white and black children.
  • Employed growth curve models to analyze changes across Tanner stages, adjusting for covariates.

Related Experiment Videos

Main Results:

  • Insulin sensitivity (SI) decreased and recovered by puberty's end in both races.
  • Acute insulin response to glucose (AIRg) linearly decreased across Tanner stages in both groups.
  • Disposition index (DI) declined throughout puberty in black youth but not in white youth.

Conclusions:

  • White and black youth experience transient insulin resistance and reduced AIRg during puberty.
  • A progressive decline in DI among black youth suggests a unique pubertal effect on beta-cell compensation.
  • This difference may contribute to the elevated type 2 diabetes risk observed in young black individuals.