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Updated: Aug 13, 2026

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
14:35

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Published on: April 17, 2021

Risk assessment in patients with depressed left ventricular function after myocardial infarction using the myocardial

Nagesh S Anavekar1, Atique Mirza, Hicham Skali

  • 1Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. nanavekar@rics.bwh.harvard.edu

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|January 21, 2006
PubMed

Insights

A higher Myocardial Performance Index (MPI) predicts adverse cardiovascular events after myocardial infarction (MI) in patients with reduced left ventricular (LV) function. This noninvasive measure offers prognostic value for high-risk individuals.

Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiac Function Assessment

Background:

  • Myocardial Performance Index (MPI) is a noninvasive Doppler measure of global cardiac function.
  • Its prognostic significance for cardiovascular (CV) events post-myocardial infarction (MI) in high-risk patients with depressed left ventricular (LV) function is unclear.

Purpose of the Study:

  • To evaluate the prognostic significance of MPI for CV events after MI.
  • To determine if MPI predicts adverse outcomes in patients with LV dysfunction.

Main Methods:

  • Analysis of echocardiograms from 512 patients post-MI with depressed LV function (SAVE substudy).
  • Baseline MPI obtained in 226 patients, stratified by median MPI of 0.50.
  • MPI correlated with baseline characteristics, ventricular remodeling, and CV events (MI, heart failure, CV death).

Main Results:

  • MPI ≥ 0.50 associated with larger infarct size and reduced LV systolic function.
  • No significant influence of baseline MPI on ventricular remodeling or its relationship with CV events.
  • Adjusted analysis showed MPI ≥ 0.50 as an independent predictor of adverse CV events (HR 2.00).

Conclusions:

  • An MPI of 0.50 or greater independently predicts CV events after MI.
  • MPI serves as a valuable prognostic tool in patients with known LV dysfunction post-MI.
Abstract

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