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Therapeutic vaccination of active arthritis with a glycosylated collagen type II peptide in complex with MHC class II

Balik Dzhambazov1, Kutty Selva Nandakumar, Jan Kihlberg

  • 1Medical Inflammation Research, Lund University, Lund, Sweden.

Journal of Immunology (Baltimore, Md. : 1950)
|January 21, 2006
PubMed

In both collagen-induced arthritis (CIA) and rheumatoid arthritis, T cells recognize a galactosylated peptide from type II collagen (CII). In this study, we demonstrate that the CII259-273 peptide, galactosylated at lysine 264, in complex with Aq molecules prevented development of CIA in mice and ameliorated chronic relapsing disease. In contrast, nonglycosylated CII259-273/Aq complexes had no such effect. CIA dependent on other MHC class II molecules (Ar/Er) was also down-regulated, indicating a bystander vaccination effect. T cells could transfer the amelioration of CIA, showing that the protection is an active process. Thus, a complex between MHC class II molecules and a posttranslationally modified peptide offers a new possibility for treatment of chronically active autoimmune inflammation such as rheumatoid arthritis.

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