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The impact of structural genomics: expectations and outcomes
John-Marc Chandonia1, Steven E Brenner
1Berkeley Structural Genomics Center, Physical Biosciences Division, Lawrence Berkeley National Laboratory, and Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA.
Structural genomics (SG) projects reduce structure determination costs, with SG centers solving half of new protein family structures. However, traditional structural biology research shows greater citation impact.
Area of Science:
- Structural biology
- Genomics
- Biochemistry
Background:
- Structural genomics (SG) aims to increase structural knowledge of biological macromolecules.
- SG projects seek to reduce the average costs associated with structure determination.
Purpose of the Study:
- To quantitatively analyze the novelty, cost, and impact of structures solved by SG centers.
- To contrast SG findings with traditional structural biology approaches.
Main Methods:
- Comparative analysis of structure determination costs.
- Evaluation of structure novelty and citation impact.
- Analysis of data from SG centers and traditional structural biology laboratories.
Main Results:
- Approximately 50% of the first structures identified in protein families were solved by SG centers by January 31, 2005.
- The cost of structure determination at efficient US SG centers dropped to one-quarter of traditional methods.
- Top traditional structural biology labs demonstrated comparable efficiency to SG centers, particularly for challenging structures.
Conclusions:
- SG centers have significantly reduced the cost and increased the accessibility of determining macromolecular structures.
- Despite cost efficiencies, traditional structural biology research continues to exhibit a higher citation impact, suggesting greater current influence.
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