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Hereditary coagulation factor X deficiency.

A Kumar1, K L Mishra, A Kumar

  • 1Department of Pathology and Pediatrics, King George Medical University, Lucknow, U.P. 226 003, India. Correspondecne to: Dr. Kusum Lata Mishra, Department of Pathology, King George Medical University, Lucknow, U.P. 226 003, India.

Indian Pediatrics
|January 21, 2006
PubMed
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Stuart Prower factor (Factor X) deficiency is a rare genetic bleeding disorder. Our study identified three cases presenting with bleeding symptoms and consanguinity, confirming severe factor X deficiency.

Area of Science:

  • Hematology
  • Genetics
  • Coagulation Disorders

Background:

  • Stuart Prower factor (Factor X) deficiency is a rare autosomal recessive coagulation disorder.
  • It is characterized by impaired blood clotting, leading to bleeding tendencies.

Purpose of the Study:

  • To report on three cases of severe factor X deficiency observed over 20 years.
  • To correlate clinical manifestations with hematological findings in these patients.

Main Methods:

  • Retrospective review of three patients diagnosed with factor X deficiency.
  • Clinical data collection including bleeding history, physical examination, and family history (consanguinity).
  • Hematological analysis to confirm and quantify factor X levels.

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Main Results:

  • Three cases of severe factor X deficiency were identified over a 20-year period.
  • Patients presented with prolonged bleeding after minor trauma, epistaxis, and subcutaneous nodules.
  • Two patients had a history of parental consanguinity, suggesting a genetic link.

Conclusions:

  • Severe factor X deficiency can manifest with characteristic bleeding symptoms.
  • Consanguinity may be a significant factor in the inheritance of this rare disorder.
  • Early diagnosis and management are crucial for patients with factor X deficiency.