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Updated: Aug 13, 2026

A Data-Driven Approach to Quantifying Immune States in Sepsis
Published on: February 7, 2025
[Sepsis--clinical parameters of recognition and differentiation]
1Klinika za infektivne bolesti, Klinicki centar Univerziteta u Sarajevu, Bosna i Hercegovina.
Introduction:
Even today, early recognition of sepsis remains a great problem, requiring the search for clinical symptoms and signs with predictive features.
Aim:
to define the number of days of disease till hospitalization and value of some clinical signs in recognition and differentiation of patients with monomicrobial (M.A) gram positive and gram negative sepsis.
Patients And Methods:
200 patients with clear clinical and laboratory signs of sepsis, septic shock and monomicrobial aerobic bacterial isolate were included randomly. Patients are divided into two equal groups.
Results:
patients with gram negative (m.a.) sepsis are hospitalized earlier relating to patients with gram positive sepsis (X2= 24,345; p< 0.001). Significance of differences in two basic groups of sepsis is the most evident for heart murmur (t=6,703; p<0,0001), shivers (t=3,313; p<0,001), afebrility (t=16,148; p<0,001), fatigue-exhaustion (t=4,472; p<0,001), pulmonary manifestations (t=3,497; p<0,001).
Conclusions:
results of investigation show the recognition of clinical symptoms and signs of sepsis, which enables the differentiation between gram positive and gram negative. Initially, this provides clinicians with a greater therapeutic reliability.
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