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Nitrone spin on cerebral ischemia.
1Division of Health Practice, Auckland University of Technology-Akoranga Campus, 90 Akoranga Drive, Northcote, Auckland, New Zealand. s.doggrell@xtra.co.nz
Current Opinion in Investigational Drugs (London, England : 2000)
|January 24, 2006
Summary
New antioxidants called nitrones show promise for treating ischemic stroke, unlike older antioxidants. These spin traps effectively neutralize harmful radicals, offering hope for neuroprotection in cerebral ischemia treatment.
Area of Science:
- Neuroscience
- Pharmacology
- Biochemistry
Background:
- Radical scavenging antioxidants have yielded limited success in treating ischemic stroke.
- Reactive radicals play a significant role in the pathophysiology of cerebral ischemia.
Purpose of the Study:
- To evaluate the potential of spin trap nitrones as a novel therapeutic strategy for ischemic stroke.
- To highlight the development of second-generation nitrones with enhanced neuroprotective properties.
Main Methods:
- Investigated the mechanism of action of spin trap nitrones in covalently binding and inactivating reactive radicals.
- Reviewed efficacy of NXY-059 in animal models of cerebral ischemia.
- Examined neuroprotective effects of second-generation azulenyl nitrones in preclinical models.
Main Results:
- Spin trap nitrones demonstrate a more sustained inactivation of reactive radicals compared to conventional antioxidants.
- NXY-059 has shown efficacy in animal models and is currently in Phase III clinical trials for ischemic stroke.
- Second-generation nitrones exhibit significant neuroprotective capabilities in animal studies.
Conclusions:
- Spin trap nitrones represent a promising class of antioxidants for the treatment of cerebral ischemia.
- The development of potent antioxidants like NXY-059 and second-generation nitrones offers significant therapeutic potential for ischemic stroke.