Related Experiment Video

Updated: Aug 13, 2026

Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice
08:41

Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice

Published on: December 29, 2016

Nitrone spin on cerebral ischemia

Sheila A Doggrell1

  • 1Division of Health Practice, Auckland University of Technology-Akoranga Campus, 90 Akoranga Drive, Northcote, Auckland, New Zealand. s.doggrell@xtra.co.nz

Current Opinion in Investigational Drugs (London, England : 2000)
|January 24, 2006
PubMed

Insights

New antioxidants called nitrones show promise for treating ischemic stroke, unlike older antioxidants. These spin traps effectively neutralize harmful radicals, offering hope for neuroprotection in cerebral ischemia treatment.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Biochemistry

Background:

  • Radical scavenging antioxidants have yielded limited success in treating ischemic stroke.
  • Reactive radicals play a significant role in the pathophysiology of cerebral ischemia.

Purpose of the Study:

  • To evaluate the potential of spin trap nitrones as a novel therapeutic strategy for ischemic stroke.
  • To highlight the development of second-generation nitrones with enhanced neuroprotective properties.

Main Methods:

  • Investigated the mechanism of action of spin trap nitrones in covalently binding and inactivating reactive radicals.
  • Reviewed efficacy of NXY-059 in animal models of cerebral ischemia.
  • Examined neuroprotective effects of second-generation azulenyl nitrones in preclinical models.

Main Results:

  • Spin trap nitrones demonstrate a more sustained inactivation of reactive radicals compared to conventional antioxidants.
  • NXY-059 has shown efficacy in animal models and is currently in Phase III clinical trials for ischemic stroke.
  • Second-generation nitrones exhibit significant neuroprotective capabilities in animal studies.

Conclusions:

  • Spin trap nitrones represent a promising class of antioxidants for the treatment of cerebral ischemia.
  • The development of potent antioxidants like NXY-059 and second-generation nitrones offers significant therapeutic potential for ischemic stroke.

More Related Videos

Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia07:46

Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia

Published on: May 9, 2013

Cerebral Ischemic Coma Model Induced by Modified Four-Vessel Occlusion03:37

Cerebral Ischemic Coma Model Induced by Modified Four-Vessel Occlusion

Published on: July 5, 2024

Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.