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Updated: Aug 13, 2026

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages
Published on: August 12, 2019
Human endotoxemia induces down-regulation of monocyte CC chemokine receptor 2
Michael Heesen1, Rosemarijn Renckens, Alex F de Vos
1Department of Anesthesia, Bamberg Hospital and University Hospital Aachen, Bamberg, Germany. michael.heesen@sozialstiftung-bamberg.de
Abstract:
Upon injection of Escherichia coli lipopolysaccharide into human volunteers, the monocyte density of CC chemokine receptor 2 (CCR2) decreased. Minimal CCR2 density was observed 4 h after injection. Peak plasma concentrations of the CCR2 ligand monocyte chemotactic protein 1 and of tumor necrosis factor alpha were reached after 4 h and 2 h, respectively.
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