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Updated: Aug 13, 2026

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
Published on: June 17, 2015
Proteomic maps-toxicity relationship of halocarbons studied with similarity index and genetic algorithm
Marjan Vracko1, Subhash C Basak, Kevin Geiss
1National Institute of Chemistry, Ljubljana, Slovenia. marjan.vracko@ki.si
Abstract:
In this work we analyzed proteomic maps obtained from hepatocytes, which were treated with 14 halocarbons. A similarity index was introduced as a robust measure of similarity between two maps or between two selections of spots within the maps. A searching algorithm was used to identify the spots that may play an important role in toxicity mechanism. The highest correlation coefficients obtained between the similarity index and biological parameter were larger than 0.9.
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