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Updated: Aug 13, 2026

Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
Activation of c-Jun N-terminal kinases by ribotoxic stresses
Dong Yun Ouyang1, Yuan Yuan Wang, Yong Tang Zheng
1Key Laboratory of Animal Models and Human Diseases Mechanisms, and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
Abstract:
The c-Jun N-terminal kinases (JNKs) are classic stress-activated protein kinases. Many cellular stresses have been shown to stimulate JNK activation. In this review, we focus on ribotoxic stresses based on their multiple biological potencies including anti-HIV-1 activity. Some of the functions of ribotoxins and the signaling transduction pathway that mediated are mentioned. Different from other stimulators, ribotoxic stresses act on special motifs of 28S rRNA in translationally active mammal ribosomes. Binding and damaging on the motif leads to JNK activation and subsequently biological response to the signal initiator, which is named ribotoxic stress response.
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