Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aromatase expression in the human temporal cortex.

J G Yague1, A Muñoz, P de Monasterio-Schrader

  • 1Instituto Cajal, Consejo Superior de Investigaciones Cientificas, E-28002 Madrid, Spain.

Neuroscience
|January 24, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Recurrent spontaneous carotid dissection].

Revista de neurologia·2000
Same author

Safety and efficacy of Omniscan (gadodiamide injection) at 0.1 mmol/kg for MRI in infants younger than 6 months of age: phase III open multicenter study.

Investigative radiology·2000
Same author

Percutaneous vertebroplasty: a special syringe for cement injection.

AJNR. American journal of neuroradiology·2000
Same author

OESCLIM: an advanced delivery system for HRT.

Maturitas·2000
Same author

Fenfluramine-induced increase in preproenkephalin mRNA levels in the striatum: interaction between the serotonergic, glutamatergic, and dopaminergic systems.

Synapse (New York, N.Y.)·2000
Same author

Autologous stem cell transplantation for advanced Hodgkin's disease in children. Spanish group for BMT in children (GETMON), Spain.

Bone marrow transplantation·2000
Same journal

Socioeconomic status impacts metacognition of working memory and emotion recognition.

Neuroscience·2026
Same journal

EEG oscillatory correlates of meditation practice: a systematic review and exploratory meta-analysis.

Neuroscience·2026
Same journal

Chronic stress primes TLR3-mediated systemic inflammation to produce persistent post-viral fatigue syndrome-like symptoms in mice.

Neuroscience·2026
Same journal

Contribution of muscarinic acetylcholine receptors to bottom-up amplification of frontal and parietal cortical responses to rare deviant tones in rats.

Neuroscience·2026
Same journal

Developmental switch of GABAergic signaling in starburst amacrine cells driven by chloride transporter dynamics.

Neuroscience·2026
Same journal

Epileptiform discharges are associated with increased theta activity over time in patients with Lewy body dementia.

Neuroscience·2026
See all related articles

Human brain aromatase (CYP19A1) expression is complex, with multiple exon I variants found in the cerebral cortex. This enzyme is present in neurons and astrocytes, suggesting local estrogen synthesis impacts brain function.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Molecular Biology

Background:

  • The human CYP19 gene encodes P450 aromatase, crucial for estrogen biosynthesis.
  • Aromatase expression in the human cerebral cortex is known but lacks detailed characterization of its regulation and cellular localization.
  • Understanding CYP19 regulation and distribution is key to understanding local estrogen's role in the brain.

Purpose of the Study:

  • To investigate the variants of exon I of the human CYP19 gene in the cerebral cortex.
  • To determine the precise cellular distribution of aromatase in the human temporal cortex.
  • To elucidate the complex regulation and functional implications of aromatase in the human brain.

Main Methods:

  • Polymerase Chain Reaction (PCR) analysis to identify CYP19 exon I variants.

Related Experiment Videos

  • Immunohistochemistry to localize aromatase protein within the human temporal cortex.
  • Analysis of neuronal and glial subpopulations, including GABAergic interneurons.

    • Main Results:

    • Four distinct variants of CYP19 exon I were identified, indicating complex gene regulation in the cerebral cortex.
    • Aromatase was primarily localized in pyramidal neurons and a subset of astrocytes.
    • Most GABAergic interneurons, identified by calcium-binding proteins, lacked aromatase immunoreactivity.

    Conclusions:

    • The diverse exon I variants suggest intricate regulation of CYP19 in the human cerebral cortex.
    • Widespread aromatase expression in specific neuronal and glial cells points to significant local estrogen production.
    • Local estrogen synthesis in the brain may play a vital role in human cortical functions.