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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
Splenic small B-cell lymphoma with IGH/BCL3 translocation
Lorinda A Soma1, Susanne M Gollin, Ellen D Remstein
1Division of Hematopathology, University of Pittsburgh School of Medicine, PA 15213, USA.
Human Pathology
|January 24, 2006
Summary
The IGH/BCL3 translocation, often seen in lymphomas, may define a new B-cell neoplasm. This rare translocation was found in a unique splenic lymphoma case not fitting classic categories.
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- Chromosomal translocations are key in non-Hodgkin lymphomas, particularly B-cell types.
- The clinical significance of IGH/BCL3 translocations remains poorly understood.
- IGH/BCL3 translocations are sometimes associated with atypical chronic lymphocytic leukemia, but documented cases are scarce.
Observation:
- A rare splenic B-cell lymphoma case presented with specific immunophenotypic markers (CD5-, CD10-, CD43-, CD23-, CD103-, FMC7+, CD25+) and epithelioid histiocyte clusters.
- Classical cytogenetics, chromosomal painting, and FISH confirmed a t(14;19)(q32;q13) translocation, identifying an IGH/BCL3 fusion.
- This case did not align with established B-cell lymphoma classifications, including chronic lymphocytic leukemia/small lymphocytic lymphoma.
Findings:
- The identified IGH/BCL3 translocation in this unique splenic B-cell lymphoma case.
- Review of prior neoplasms with t(14;19) or IGH/BCL3 translocations.
- The distinct clinicopathologic features of the presented case.
Implications:
- The IGH/BCL3 translocation may serve as a diagnostic marker for a novel clinicopathologic entity.
- Further research into this translocation could refine lymphoma classification and understanding.
- This finding highlights the importance of detailed genetic analysis in diagnosing rare B-cell neoplasms.
