Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell-cell interactions in synaptogenesis.

Michael R Akins1, Thomas Biederer

  • 1Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.

Current Opinion in Neurobiology
|January 24, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

All-optical visualization of specific molecules in the ultrastructural context of brain tissue.

Nature biotechnology·2025
Same author

High-content image-based pooled screens reveal regulators of synaptogenesis.

Cell reports·2025
Same author

Progressive vulnerability of cortical synapses in α-synucleinopathy.

bioRxiv : the preprint server for biology·2025
Same author

A complex of the lipid transport ER proteins TMEM24 and C2CD2 with band 4.1 at cell-cell contacts.

The Journal of cell biology·2024
Same author

Transient impairment in microglial function causes sex-specific deficits in synaptic maturity and hippocampal function in mice exposed to early adversity.

Brain, behavior, and immunity·2024
Same author

Transient Impairment in Microglial Function Causes Sex-Specific Deficits in Synaptic and Hippocampal Function in Mice Exposed to Early Adversity.

bioRxiv : the preprint server for biology·2024
Same journal

Population codes for context-dependent decision-making.

Current opinion in neurobiology·2026
Same journal

Cichlid fish as a model for understanding social dysfunction.

Current opinion in neurobiology·2026
Same journal

On aims and methods in field neuroethology: Investigating neural mechanisms of behavior in semi-natural and natural contexts.

Current opinion in neurobiology·2026
Same journal

Neurobiological interfaces connecting environmental change to monarch butterfly migration.

Current opinion in neurobiology·2026
Same journal

Learning how to experience the world: From circuits to cell types to genes.

Current opinion in neurobiology·2026
Same journal

Editorial overview for neurobiology of disease 2026.

Current opinion in neurobiology·2026
See all related articles

Synaptogenesis, the formation of neuronal connections, relies on precise molecular cues and cell surface interactions. These interactions guide the assembly of essential synaptic components for neuronal communication.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Synaptogenesis is a critical process for establishing neural circuits.
  • It involves precise temporal and spatial coordination between neurons.
  • Understanding the molecular mechanisms is key to comprehending brain function.

Purpose of the Study:

  • To identify molecular cues guiding synaptogenesis.
  • To elucidate the role of cell surface interactions in synapse formation.
  • To explore the function of adhesion and signaling molecules in synaptic specialization.

Main Methods:

  • Investigating molecular cues involved in neuronal communication.
  • Analyzing cell surface interactions at synaptic sites.
  • Studying the recruitment of scaffolding and adhesion molecules.

Related Experiment Videos

Main Results:

  • Identified key molecular cues that orchestrate synaptogenesis.
  • Highlighted the prominent role of cell surface interactions, including trans-synaptic adhesion.
  • Demonstrated the involvement of non-neuronal cells and extracellular matrix in synapse formation.
  • Showcased the recruitment of essential synaptic components through these interactions.

Conclusions:

  • Molecular cues and cell surface interactions are fundamental to synaptogenesis.
  • Adhesion and signaling molecules play crucial roles in forming functional synaptic specializations.
  • Further research into these molecules will provide deeper insights into brain development and function.