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Do burn patients have a silver lining?

C J Coombs1, A T Wan, J P Masterton

  • 1Burns Unit, Alfred Hospital, Melbourne, Australia.

Burns : Journal of the International Society for Burn Injuries
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

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Silver sulphadiazine cream (SSD) effectively treats burn wound infections, with silver rapidly absorbing into the body. While silver deposits in organs, it appears safe for moderate burns, though high levels in severe cases warrant further study.

Area of Science:

  • Pharmacology
  • Wound Management
  • Toxicology

Background:

  • Silver-containing drugs have a long history in burn wound care.
  • Silver sulphadiazine cream (SSD) is a prevalent treatment for burn wound sepsis.

Purpose of the Study:

  • To investigate silver ion absorption and its effects on hepatic and renal function following SSD application.
  • To assess silver deposition in organs and its correlation with patient outcomes.

Main Methods:

  • A prospective clinical study involving 22 patients treated with SSD.
  • Silver levels quantified using atomic absorption spectrophotometry with a graphite furnace.
  • Biochemical and electron microscopic analysis of tissue samples for silver deposition.

Main Results:

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  • Rapid absorption of silver from SSD through burn wounds was observed.
  • Elevated serum silver levels were detected in 20 out of 22 patients.
  • Silver deposition occurred in the liver and kidneys, particularly in a patient who died.
  • Early hepatic dysfunction was noted in burns exceeding 10% total body surface area.
  • No correlation between liver/renal function tests and serum silver levels.

Conclusions:

  • Silver is readily absorbed from SSD and deposits systemically.
  • SSD appears safe for treating moderate burns.
  • The safety of very high silver levels in severe burns requires further investigation.