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Updated: Aug 13, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Bullous hemorrhagic dermatosis occurring at sites distant from subcutaneous injections of heparin: three cases
Adeline Perrinaud1, David Jacobi, Marie-Christine Machet
1Department of Dermatology, Université François-Rabelais, University Hospital of Tours, Tours, France.
Abstract:
Cutaneous side effects from heparin administration are rare and usually located at injection sites. We report 3 cases of intraepidermal hemorrhagic blisters occurring distant from sites of subcutaneous injections of heparin. A causative link is suggested by a temporal relationship between heparin introduction and onset of disease as well as exclusion of other causes, but the mechanism remains unknown.
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