Related Experiment Video
Updated: Aug 13, 2026
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
Early postnatal allopurinol does not improve short term outcome after severe birth asphyxia
M J N L Benders1, A F Bos, C M A Rademaker
1Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center KE 4.123.1, PO Box 85090, 3508 AB Utrecht, the Netherlands. m.benders@azu.nl
Objective:
To investigate whether postnatal allopurinol would reduce free radical induced reperfusion/reoxygenation injury of the brain in severely asphyxiated neonates.
Method:
In an interim analysis of a randomised, double blind, placebo controlled study, 32 severely asphyxiated infants were given allopurinol or a vehicle within four hours of birth.
Results:
The analysis showed an unaltered (high) mortality and morbidity in the infants treated with allopurinol.
Conclusion:
Allopurinol treatment started postnatally was too late to reduce the early reperfusion induced free radical surge. Allopurinol administration to the fetus with (imminent) hypoxia via the mother during labour may be more effective in reducing free radical induced post-asphyxial brain damage.
