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Diffusion imaging of the prostate at 3.0 tesla
Peter Gibbs1, Martin D Pickles, Lindsay W Turnbull
1Centre for MR Investigations, Division of Cancer, Postgraduate Medical School, University of Hull, Hull, United Kingdom. p.gibbs@hull.ac.uk
Investigative Radiology
|January 24, 2006
Summary
Diffusion imaging effectively differentiates prostate cancer. This technique shows reduced apparent diffusion coefficient (ADC) and increased fractional anisotropy in cancerous tissue, aiding diagnosis.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Prostate cancer diagnosis relies on imaging.
- Diffusion imaging offers insights into tissue microstructure.
Purpose of the Study:
- To evaluate diffusion imaging's efficacy in diagnosing prostate cancer.
- To utilize a 3.0 T scanner and parallel imaging technology.
Main Methods:
- Acquired diffusion-weighted images (b=0, 500 s/mm²) and diffusion tensor images.
- Calculated apparent diffusion coefficient (ADC), mean diffusivity, and fractional anisotropy in 62 patients.
Main Results:
- Prostate cancer showed significantly lower ADC values (1.33 x 10⁻³ mm²/s) compared to healthy tissue (1.86 x 10⁻³ mm²/s).
- Mean diffusivity and fractional anisotropy also differed significantly between tumor and healthy tissue.
- A mean diffusivity cutoff of 1.45 x 10⁻³ mm/s achieved 84% sensitivity and 80% specificity.
Conclusions:
- Diffusion imaging is feasible at high magnetic field strength (3.0 T) for prostate evaluation.
- Reduced ADC and increased fractional anisotropy are characteristic of prostate carcinoma.