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Related Experiment Videos

Three-dimensional T1 mapping for dGEMRIC at 3.0 T using the Look Locker method.

Tali Kimelman1, Anthony Vu, Pippa Storey

  • 1Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA.

Investigative Radiology
|January 24, 2006
PubMed
Summary

This study validated a new 3D T1 mapping sequence (3DLL) for delayed Gadolinium-Enhanced MRI of Cartilage (dGEMRIC) at 3.0 T. The 3DLL sequence accurately measures T1 values, offering a faster and comprehensive joint assessment.

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Biomedical Engineering
  • Radiology

Background:

  • Delayed Gadolinium-Enhanced MRI of Cartilage (dGEMRIC) is crucial for assessing cartilage health.
  • Current dGEMRIC protocols primarily use 2D IR fast spin echo (FSE) at 1.5 T.
  • Higher field strengths (3.0 T) and advanced sequences may improve dGEMRIC accuracy and efficiency.

Purpose of the Study:

  • To implement and evaluate a novel three-dimensional (3D) T1 mapping sequence (3DLL) at 3.0 T for dGEMRIC.
  • To compare the performance of the 3DLL sequence with the conventional 2D IR-FSE sequence at both 1.5 T and 3.0 T.
  • To assess the accuracy and speed of the 3DLL sequence for joint imaging.

Main Methods:

  • Acquired data at 1.5 T and 3.0 T using both 3DLL and 2D IR-FSE sequences.

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  • Utilized phantoms with varying Gd(DTPA) concentrations for calibration.
  • Scanned seven subjects (three asymptomatic, four symptomatic) using the dGEMRIC technique.

    • Main Results:

    • T1 measurements from the 3DLL sequence showed excellent agreement with the 2D IR-FSE sequence in phantom studies.
    • Statistical analysis revealed no significant difference in T1 (Gd) measurements between the two sequences in subjects at both 1.5 T (P = 0.07) and 3.0 T (P = 0.07).

    Conclusions:

    • The 3DLL sequence demonstrates accurate T1 value measurements for dGEMRIC at 3.0 T.
    • The sequence provides adequate in-plane resolution for clinical application.
    • The 3DLL sequence enables complete joint coverage in under 10 minutes, enhancing imaging efficiency.